Rat Formulary

Anesthetics
Drug Name Dose (mg/kg) Route Notes
Ketamine 751 Intraperitoneal Not generally adequate for deep anesthesia
Ketamine-Xylazine 40-80 (K); 5-10 (X)1
75-95 (K); 5 (X)2
Intraperitoneal If re-dosing, use ketamine only; do not exceed 148 mg/kg total ketamine dose
Isoflurane To effect Inhalational
For vaporizer use, >3% is typical for induction and 1-3% is typical for maintenance anesthesia.

Open drop technique must be performed within ventilated work station.

 

Analgesics
Drug Name Dose (mg/kg) Route Frequency Notes
Buprenorphine 0.051 Subcutaneous Every 8-12 hours Opioid
Carprofen 53 Subcutaneous Every 12-24 hours Nonsteroidal anti-inflammatory drug
Ketoprofen 53 Subcutaneous; Oral Every 12-24 hours Nonsteroidal anti-inflammatory drug
Meloxicam 23 Subcutaneous; Oral Every 24 hours Nonsteroidal anti-inflammatory drug
 
 

Mouse Formulary

Anesthetics
Drug Name Dose (mg/kg) Route Notes
Ketamine 100-2001 Intraperitoneal Not generally adequate for deep anesthesia
Ketamine-Xylazine 90-120 (K); 10 (X)1
50 (K); 5 (X)2
Intraperitoneal If re-dosing only re-dose ketamine
Ketamine (K), Xylazine (X), and Acepromazine (A) 30 (K); 6 (X); 1 (A)1
65 (K); 13 (X); 2 (A)1
Intraperitoneal If re-dosing only re-dose ketamine
Isoflurane To effect Inhalational
For vaporizer use, >3% is typical for induction and 1-3% is typical for maintenance anesthesia.

Open drop technique must be performed within ventilated work station.

 

Analgesics
Drug Name Dose (mg/kg) Route Frequency Notes
Buprenorphine 21 Subcutaneous Every 12 hours Opioid
Carprofen 52 Subcutaneous Every 24 hours Nonsteroidal anti-inflammatory drug
Ketoprofen 53 Subcutaneous; Oral Every 12-24 hours
Nonsteroidal anti-inflammatory drug
Meloxicam 53 Subcutaneous; Oral Every 24 hours Nonsteroidal anti-inflammatory drug

References
1.  Hawk, C.  T., Leary, S.  L., & Morris, T.  H.  (2005).  Formulary for laboratory animals (3rd ed.).  Aimes,
IA:  Blackwell Publishing.
2.  Carpenter, J.  W.  (2005).  Exotic animal formulary (3rd ed.).  St. Louis, MO:  Elsevier Saunders.
3.  Quesenberry, K.  E.  & Carpenter, J.  W.  (2012).  Ferrets, rabbits, and rodents clinical medicine and
surgery (3rd ed.).  St. Louis, MO:  Elsevier Saunders. 

Revision history:
Revised April 20, 2016


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